McNeill trainees and staff underlined

I. Research Publications

Tsatskis Y, Rosenfeld R, Pearson JD, Boswell C, Qu Y, Kim K, Fabian L, Mohammad A, Wang X, Robson MI, Krchma K, Wu J, Gonçalves J, Hodzic D, Wu S, Pelletier L, Dunham WH, Gingram AC, Sun Y, Meng J, Godt D, Schedl T, Ciruna B, Choi K, Perry JRB, Bremner R, Schirmer EC, Brill JA, Jurisicova A, McNeill H. The NEMP family supports metazoan fertility and nuclear envelope stiffness. Science Advances. 2020 Aug 1;6(35):eabb4591.

Brooun M, Klimovich A, Bashkurov M, Pearson BJ, Steele RE, McNeill H. Ancestral roles of atypical cadherins in planar cell polarity. Proc Natl Acad Sci U S A. 2020 Jul 29:201917570. doi: 10.1073/pnas.1917570117. Online ahead of print.

Betterman KL, Sutton DL, Secker GA, Kazenwadel J, Oszmiana A, Lim L, Miura N, Sorokin L, Hogan BM, Kahn ML, McNeill H, Harvey NL. Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. J Clin Invest. 2020 Jun 1;130(6):3315-3328. doi: 10.1172/JCI99027.

Rao-Bhatia A, Zhu M, Yin WC, Coquenlorge S, Zhang X, Woo J, Sun Y, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim TH. Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Dev Cell. 2020 Mar 9;52(5):647-658.e6. doi: 10.1016/j.devcel.2020.02.003.

Shea CA, Rolfe RA, McNeill H, Murphy P. Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation. Dev Dyn. 2020 Apr;249(4):523-542. doi: 10.1002/dvdy.137. Epub 2019 Dec 16.

Fulford AD, McNeill H. Fat/Dachsous family cadherins in cell and tissue organisation. Curr Opin Cell Biol. 2020 Feb;62:96-103. doi: 10.1016/j.ceb.2019.10.006. Epub 2019 Nov 15.

Formica C, Happé H, Veraar KA, Vortkamp A, Scharpfenecker M, McNeill H, Peters DJ. Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury. J Pathol. 2019 Sep;249(1):114-125. doi: 10.1002/path.5286. Epub 2019 Jun 17. 

Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, Kuure S, Jain S, McNeill H.  FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling. Dev Cell. 2019  48(6):780-792.e4. doi: 10.1016/j.devcel.2019.02.004.

Arbouzova NI, Fulford AD, Zhang H, McNeill H.    Fat regulates expression of four-jointed reporters in vivo through a 20 bp element independently of the Hippo pathway. Dev Biol. 2019 Mar 9. pii: S0012-1606(18)30668-7

Lahrouchi N, George A, Ratbi I, Schneider R, Elalaoui SC, Moosa S, Bharti S, Sharma R, Abu-Asab M, Onojafe F, Adadi N, Lodder EM, Laarabi FZ, Lamsyah Y, Elorch H, Chebbar I, Postma AV, Lougaris V, Plebani A, Altmueller J, Kyrieleis H, Meiner V, McNeill H, Bharti K, Lyonnet S, Wollnik B, Henrion-Caude A, Berraho A, Hildebrandt F, Bezzina CR, Brooks BP, Sefiani A. Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly. Nat Commun. 2019 Mar 2;10(1):1180.

Chen J, Castelvecchi GD, Li-Villarreal N, Raught B, Krezel AM, McNeill H, Solnica-Krezel L. Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages. Dev Cell. 2018 May 7;45(3):376-391

Wang X, Liu H, Zhu M, Cao C, Xu Z, Tsatskis Y, Lau K, Kuok C, Filleter T, McNeill H, Simmons CA, Hopyan S, Sun Y.  Mechanical stability of the cell nucleus – roles played by the cytoskeleton in nuclear deformation and strain recovery. J Cell Sci. 2018 Jul 4;131(13).

Neirijnck Y, Reginensi A, Renkema KY, Massa F, Kozlov VM, Dhib H, Bongers EMHF, Feitz WF, van Eerde AM, Lefebvre V, Knoers NVAM, Tabatabaei M, Schulz H, McNeill H, Schaefer F, Wegner M, Sock E, Schedl A. Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT).  Kidney Int. 2018 May;93(5):1142-1153

Hoshi M, Reginensi A, Joens MS, Fitzpatrick JAJ, McNeill H, Jain S. Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion. J Am Soc Nephrol. 2018 Mar;29(3):775-783

Blair S & McNeill H. Big roles for Fat cadherins.Curr Opin Cell Biol. 2018 Apr;51:73-80

McNeill H, Reginensi A. Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation. (2017) J Am Soc Nephrol, 28, 852-861.

Yeung K, Boija A, Karlsson E, Holmqvist P-H, Tsatskis Y, Nisoli I, Yap D, Lorzadeh A, Moksa M, Hirst M, Aparicio S, Fanto M, Stenberg P, Mannervik M, McNeill H. Atrophin controls developmental signaling pathways via interactions with Trithorax-like. (2017) eLife,Mar 22;6. pii: e23084. doi: 10.1681/ASN.2016060611..

Ragni CV, Diguet N, Le Garrec J-F, Pop S, Charon N, Badouel C, Dufour A, Olivo-Marin J-C, Trouvé A, McNeill, H, Meilhac SM. Amotl1 mediates non-canonical Hippo signalling downstream of Fat4 to restrict heart growth. (2017) Nature Communications, 8, 14582.

Kwan J, Sczaniecka A, Arash EH, Nguyen L, Chen C-C, Ratkovic S, Klezovitch O, Attisano L, McNeill H, Emili A, Vasioukhin V. DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. (2016) Genes & Dev, 30, 2696-2709.

Delanoue R, Meschi E, Agrawal N, Mauri A, Tsatskis YMcNeill H, Léopold P. Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor. (2016) Science,353, 1553-1556.

Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. (2016) Nat Commun, 7, 12309.

Payankaulam S, Yeung KMcNeill H, Henry RW, Arnosti DN. Regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein. (2016) Scientific Reports, 6, 22879

Gee HY, Sadowski CE, Aggarwal PK, Porath JD, Yakulov TA, Schueler M, Lovric S, Ashraf S, Braun DA, Halbritter J, Fang H, Airik R, Vega-Warner V, Cho KJ, Chan TA, Morris LG, Ffrench-Constant C, Allen N, McNeill H, Büscher R, Kyrieleis H, Wallot M, Gaspert A, Kistler T, Milford DV, Saleem MA, Keng WT, Alexander SI, Valentini RP, Licht C, Teh JC, Bogdanovic R, Koziell A, Bierzynska A, Soliman NA, Otto EA, Lifton RP, Holzman LB, Sibinga NE, Walz G, Tufro A, Hildebrandt F. FAT1 mutations cause a glomerulotubular nephropathy. (2016) Nature Communications, 24, 10822.

Chang YJ, Zhou L, Binari R, Manoukian A, Mak T, McNeill H, Stambolic V. The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila. (2016) PLoS One, 11, e0152259.

Chiu CW, Monat C, Robitaille M, Lacomme M, Daulat AM, Macleod G, McNeill H, Cayouette M, Angers S. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. (2016) Dev Cell, 36, 50-62.

Schwartzman M*, Reginensi A*, Wong JS, Basgen JM, Meliambro K, Nicholas SB, D’Agati V, McNeill H, Campbell KN. Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure. (2016) J Am Soc Nephrol, 27, 216-26.

Badouel C, Zander MA, Liscio N, Bagherie-Lachidan M, Sopko R, Coyaud E, Raught B, Miller FD, McNeill H. Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development. (2015).Development, 142, 2787-91.

Reginensi A, Hoshi M, Boualia SK, Bouchard M, Jain S, McNeill H. Yap and Taz are Required for Ret-Dependent Urinary Tract Morphogenesis. (2015) Development, 142, 2696-703.

Bagherie-Lachidan M, Reginensi A, Pan Q, Zaveri HP, Scott DA, Blencowe BJ, Helmbacher F, McNeill H. Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. (2015) Development, 142, 2564-73.

Sugiyama Y, Shelley EJ, Badouel CMcNeill H, McAvoy JW. Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation. (2015) Invest Ophthalmol Vis Sci, 56, 4099-107.

Sing A, Tsatskis Y, Fabian L, Bietenhader M, Stolz T, Rosenfeld R, Brill J, McQuibban GA, McNeill H. The atypical cadherin Fat directly regulates mitochondrial function and metabolic state. (2014) Cell, 158, 1293-1308.

Avet-Rochex A, Carvajal N, Christoforou CP, Yeung K, Maierbrugger KT, Hobbs C, Lalli G, Cagin U, Plachot CMcNeill H, Bateman JM. Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control. (2014) PLoS Genet, 10, e1004624.

Zakaria S, Mao Y, de Sousa C, Kuta A, Gaufo G, McNeill H, Hindges R, Guthrie S, Irvine KD, Francis-West PH. Regulation of neuronal migration by Dchs1-Fat4 planar cell polarity. (2014) Current Biology, 24, 1620-7.

Bossuyt W, Chen CL, Chen Q, Sudol M, McNeill H, Pan D, Kopp A, Halder G. An evolutionary shift in the regulation of the Hippo pathway between mice and flies. (2014) Oncogene, 33, 1218-28.

Belozerov VE, Ratkovic SMcNeill H, Hilliker AJ, McDermott JC. In vivo interaction proteomics reveal a novel p38MAPK/Rack1 pathway regulating proteostasis in Drosophila muscle. (2014) Molecular Cell Biology, 34, 474-84

Cappello S, Gray MJ, Badouel C, Lange S, Einsiedler M, Srour M, Chitayat D, Hamdan FF, Jenkins ZA, Morgan T, Preitner N, Uster T, Thomas J , Shannon P, Morrison V, Di Donato N, Van Maldergem L, Neuhann T, Newbury-Ecob R, Swinkells M, Terhal P, Wilson LC, Zwijnenburg PJG, Sutherland-Smith AJ, Black MA, Markie D, Michaud JL, Simpson MA, Mansour S, McNeill H, Götz M, Robertson SP. Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development (2013) Nature Genetics, 45, 1300-8.

Sharma PP, McNeill H. Regulation of long-range planar cell polarity by Fat-Dachsous signaling. (2013) Development, 140, 3869-81.

Reginensi R, Scott R, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim D-S, Pawson T, Wrana J, McNeill H. Yap- and Cdc42-Dependent nephrogenesis and morphogenesis during Mouse Kidney Development. (2013) PLoS Genetics, 9, e1003380.

Brooun M, Manoukian A, Shimizu H, Bode HR, McNeill H. Organizer formation in Hydra is disrupted by thalidomide treatment. (2013) Dev Biol, 378, 51-63.

Avet-Rochex A, Kaul AK, Gatt AP, McNeill H, Bateman JM. Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain. (2012) Development, 139, 2763-72.

Saburi S, Hester I, Goodrich L, McNeill H. Functional interactions between Fat-family cadherins in tissue morphogenesis and planar polarity. (2012) Development, 139, 1806-20.

Daulat AM, Luu O, Sing A, Zhang L, Wrana JL, McNeill H, Winklbauer R, Angers S. Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation. (2012) Mol Cell Biol, 32,173-85.

Walker J, Kwon SY, Badenhorst P, East P, McNeill H, Svejstrup JQ. Role of Elongator Subunit Elp3 in Drosophila Melanogaster Larval Development and Tumorigenesis. (2011) Genetics187, 1067-75.

Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson AJ, Hunziker W, McNeill H, Wrana JL, Attisano L. The Hippo Pathway Regulates Wnt/β-Catenin Signaling (2010) Developmental Cell, 18, 579-91

Sopko R, Silva E, Clayton L, Gardano L, Barrios-Rodiles M, Wrana J, Varelas X, Arbouzova NI, Shaw S, Saburi S, Matakatsu H, Blair S, McNeill HPhosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown. (2009) Current Biology, 19, 1112-7.

Badouel C, Gardano L, Amin N, Garg, A, Le Bahn T, McNeill H. The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. (2009Developmental Cell, 16, 411-20

Amin N, Khan A, St Johnston D, Tomlinson T, Martin S, Brenman J, McNeill H. LKB1 regulates cell polarity and adherens junction formation in the Drosophila retina. (2009) Proc Natl Acad Sci, 106, 8941-6.

McNeill H, Craig GM, Bateman JM. Regulation of Neurogenesis and EGFR signaling by the insulin receptor/TOR pathway. (2008) Genetics, 179, 1-11.

Saburi S, Hester I, Fischer E, Pontoglio M, Eremina V, Gessler M, Quaggin S, Harrison R, Mount R, McNeill H. Loss of Fat4 disrupts PCP signalling and oriented cell division, leading to cystic kidney disease. (2008) Nature Genetics, 40, 1010-5.

Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumour suppressor gene fat controls tissue growth upstream of Expanded in the Hippo signalling pathway. (2006) Current Biology7, 2081-2089.

Srinivasan S, Armstrong J, Dahlsveen I, McNeill H, Tamkun, J. The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II. (2005) Development, 132, 1623-1635

Bilioni A, Craig G, Hill C, McNeill H. Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo. (2005) Proc Natl Acad Sci,102, 14671-14676.

Bateman JM, McNeill H. Temporal control of differentiation by the insulin receptor/Tor pathway in Drosophila. (2004) Cell119, 87-96.

Fanto M, Clayton L, Meredith J, Hardiman K, Charroux B, Kerridge S, McNeill H. The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor. (2003) Development, 130, 763-774.

Ma D, Yang CH, McNeill H, Simon MA, Axelrod JD. Fidelity in planar cell polarity signalling. (2003) Nature, 421, 543-547.

Jordan KC, Clegg NJ, Blasi JA, Morimoto AM, Sen J, Stein D, McNeill H, Deng WM, Tworoger M, Ruohola-Baker H. The homeobox gene mirror links EGF signalling to embryonic dorso-ventral axis formation through Notch activation. (2000) Nature Genetics, 24, 429-433.

Yang CH, Simon M, McNeill Hmirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. (1999) Development, 126, 5857-5866.

McNeill H, Yang C, Brodsky M, Ungos J, Simon MA. mirror encodes a novel PBX-Class Homeoprotein that Defines the D/V Border in the Eye. (1997) Genes & Development, 11, 1073-1081.

Allard J, Chang H, Herbst R, McNeill H, Simon MA. The SH2-Containing tyrosine phosphatase corkscrew is required during signalling by sevenless, Ras 1 and Raf. (1996) Development122, 1137-1146.

McNeill H, Ryan TA, Smith SJ, Nelson WJ. Spatial and Temporal Dissection of Immediate and Early Events following Cadherin-Mediated Epithelial Cell Adhesion. (1993) J. Cell Biol., 1, 1217-1226.

McNeill H, Ozawa M, Kemler R, Nelson WJ. Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. (1990) Cell, 62, 309-316.

Cassimeris L, McNeill H, Zigmond SH. Chemoattractant-stimulated polymorphonuclear leukocytes contain two populations of actin filaments that differ in their spatial distributions and relative stabilities. (1990) J. Cell. Biol., 110, 1067-1075.

McNeill H, Jensen P. A high affinity receptor for urokinase plasminogen activator on human keratinocytes: characterisation and potential modulation during migration. (1990) Cell Reg., 1, 843-852.

II. Reviews

Fulford AD, McNeill H. Fat/Dachsous family cadherins in cell and tissue organisation. (2020) Current Opinion in Cell Biology, 62, 96-103.

Enderle LMcNeill H. Hippo gains weight: added insights and complexity to pathway control. (2013) Science Signaling, 6, re7.

Badouel CMcNeill H. SnapShot: The hippo signaling pathway. (2011) Cell, 145, 484-484.e1.

McNeill H, Sudol M, Halder G, Strano S, Blandino G, Shaul Y. The Hippo tumor suppressor pathway: a report on ‘the Second Workshop On The Hippo tumor suppressor pathway’. (2011) Cell Death Differ, 18, 1388-90.

McNeill H, Woodgett J. When pathways collide: collaboration and connivance among signalling proteins. (2010) Nature Reviews Molecular Cell Biology11, 404-13.

McNeill H. Planar cell polarity: keeping hairs straight is not so simple. (2010) Cold Spring Harb Perspect Biol, 2, a003376.

Bagherie-Lachidan MMcNeill HWhat Drives Cyst Formation in PKD? (2010) J. Am. Soc. Nephrol21, 200-2.

Badouel C, Garg A, McNeill H. Herding Hippos. (2009) Current Opinions in Cell Biology  21, 837-43.

McNeill, H. Planar Cell Polarity and the Kidney. (2009) J. Am. Soc. Nephrol202104-11.

Bacallao RI, McNeill H. Cystic kidney disease and planar cell polarity signaling. (2009) Clinical Genetics72107-17.

Sopko R, McNeill H. The skinny on Fat: an enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarity. (2009) Current Opinions in Cell Biology, 21, 717-23.

Badouel C, McNeill H. Apical junction and growth in Drosophila. (2009) BBA-Biomembranes; special themed issue on junctions, 469, 127-40.

Arbuzova NMcNeill H. Visualization of PCP Defects in the Eye and Wing of Drosophila melanogaster. (2008) Methods Mol Biol;Wnt Signaling: Volume 2, Pathway Models, 469, 127-140.

Bateman JM, McNeill H. Insulin/IGF signalling in neurogenesis. (2006) Cell Mol Life Sci, 63, 1701-1705.

Bateman JM, McNeill H. Seeing in color–warts and all. (2005) Dev Cell, 9, 441-442.

Saburi S, McNeill, H. Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity. (2005) Current Opinions in Cell Biology, 17, 482-488.

Leevers SJ, McNeill H. Controlling the size of organs and organisms. (2005) Current Opinions in Cell Biology, 17, 604-609.

Fanto M, McNeill H. Planar Polarity: from flies to vertebrates(2004)J Cell Science, 117, 527-533.

McNeill H. Stuck without Traffic Jam. (2003) Nat Cell Biol, 5, 948-949.

Axelrod J, McNeill H. Coupling Planar Cell Polarity Signalling to Morphogenesis. (2002) The Scientific World, 2, 434-454.

McNeill H. Planar polarity: location, location, location. (2002) Curr Biol12R449-451.

McNeill H. Sticking together and sorting things out: adhesion as a force in development. (2000) Nature Rev Genetics, 1, 100-108.

McNeill H and Downward J. Apoptosis: Ras to the rescue in the fly eye. (1999) Curr Biol, 9, 176-179.

Nelson WJ, Wilson R, Wollner D, Mays R, McNeill H, and Siemers K. Regulation of Epithelial Cell Polarity: A View From the Cell Surface. (1992) Cold Spring Harbor Symposium in Quantitative Biology, 57, 621-30.

Nelson WJ, Hammerton RW, McNeill H. Role of the membrane-cytoskeleton in the spatial organization of the Na,K-ATPase in polarized epithelial cells. (1991) Soc Gen Physiol Ser, 46, 77-87.

McNeill H, Ozawa M, Kemler R, and Nelson WJ. Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. (1990) Cell, 62, 309-16.

McNeill H, Jensen PJ. A high-affinity receptor for urokinase plasminogen activator on human keratinocytes: characterization and potential modulation during migration. (1990) Cell Regul, 1, 843-52.

Cassimeris L, McNeill H, and Zigmond SH. Chemoattractant-stimulated polymorphonuclear leukocytes contain two populations of actin filaments that differ in their spatial distributions and relative stabilities. (1990) J Cell Biol, 110, 1067-75.

III. Book Chapters

Sharma PP, McNeill, H. Fat and Dachsous cadherins. (2013) The Molecular Biology of Cadherins, Progress in Molecular Biology and Translational Science, 116, 215-235. (ed. Conn MP). Elsevier, Amsterdam.

Arbuzova N, McNeill, H. Visualization of PCP Defects in the Eye and Wing of Drosophila melanogaster. Wnt Signaling: Volume 2, Pathway Models, Methods in Molecular Biology (ed. Vincan E). Humana Press, New York. (2009), pp 127-140

McNeill H and Nelson WJ (1992). “Shaping an epithelial cell: The role of cell adhesion molecules in the reorganization of the membrane cytoskeleton”. Epithelial Organization and Development Ed. Tom Fleming. Chapman and Hall.